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. 2021 Sep 1;8:736001. doi: 10.3389/fcvm.2021.736001

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Copyright © 2021 You, Chen, Xu, Zhang, Li, Shi, Zheng and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scatter plot of the Mendelian randomization (MR) outcome. Relationship between the effect size estimates on sUMOD (x-axis) and the effect size estimates on outcomes (y-axis): Hypertension (A,B), systolic blood pressure (C,D), diastolic blood pressure (E,F). The slope of fitted lines represents the estimated causal effect of sUMOD obtained using the inverse variance weighted (IVW), MR-Egger, and weighted median (WM). Hypertension: (A) (ukb-b-14177), (B) (ukb-b-14-57); systolic blood pressure: (C) (ieu-b-38), (D) (ukb-b-20175); diastolic blood pressure: (E) (ieu-b-39), (F) (ukb-b-7992).