Figure 9.

Spectrograms of mean membrane potentials for patient E6. (A1, B1) Stimulation current $I_S^{(k)}$, (A3, B3) population firing rates r_k, and (A4, B4) mean membrane potentials v_k for the EZ (orange) and other populations (black). The blue curves show the network average firing rate and membrane potential. (A2, B2) Space-time plots of the population firing rates r_k, color-coding the value of the firing rate of each node, as a function of time. (A5, B5) Spectrogram of the network average membrane potential and (A6, B6) of the v_k of the EZ. Column A shows an asymptomatic seizure-like event for $\overline{\eta }=-14$, column B shows a generalized seizure-like event for $\overline{\eta }=-7.5$. The EZ node 77 (rh-PrG) is stimulated. Parameter values: N_pop = 88, τ_m = 20 ms, Δ = 1, σ = 1.25, J_kk = 20, $J_{kl}=5{\tilde{J}}_{kl},\forall k\ne l$. For comparison are shown the space-time plots of the population firing rates r_k (A7, B7) and the spectrogram of the network average membrane potential (A8, B8) for healthy subject H2. In accordance with the above panels, column A shows an asymptomatic seizure-like event (for $\overline{\eta }=-9.20$), column B shows a generalized seizure-like event (for $\overline{\eta }=-5.3$). The EZ node 46 is stimulated. Parameter values: N_pop = 90, τ_m = 20 ms, Δ = 1, J_kk = 20, σ = 1, $J_{kl}=5{\tilde{J}}_{kl},\forall k\ne l$.