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. 2021 Sep 1;9:642650. doi: 10.3389/fcell.2021.642650

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Copyright © 2021 Guo, Yin, Dai, Guan, Chen, Chen, Huang, Lu, Zhang and Song.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Building the methylation risk score for bladder cancer (MRSB) in the training cohort. (A) Clinical characteristics of the training and validation cohorts. (B) Clinical characteristics of the high- and low-risk groups identified by MRSB. (C) Eight CpG predictive features had the highest discriminative power for high-risk and low-risk patients. (D) Area under the curve of the receiver operating characteristic curve for MRSB to distinguish between high- and low-risk groups. (E) Progression-free survival was significantly different between the high- and low-risk groups. (F) The prognostic value of MRSB in patient subgroups with different patient and clinical features.