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. 2021 Sep 1;9:642650. doi: 10.3389/fcell.2021.642650

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Copyright © 2021 Guo, Yin, Dai, Guan, Chen, Chen, Huang, Lu, Zhang and Song.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression patterns of MRSB component-related genes. (A) Progression-free survival curves according to the presence of the MRSB component-related gene TNFAIP8L3. (B) Overall survival based on TNFAIP8L3 expression. (C) Negative correlation between TNFAIP8L3 expression and the methylation level. (D) Progression-free survival and (E) overall survival curves based on the expression of APC. (F) Negative correlation between APC expression and the methylation level in the ZZU cohort. (G) The mRNA expression levels of TNFAIP8L3 in the cancer and adjacent tissues (p < 0.001, ZZU cohort). (H) The protein expression levels of TNFAIP8L3, **p < 0.001. MRSB, methylation risk score for bladder cancer; ZZU, Zhengzhou University.