Figure 3.

Heterochromatin features are transiently established following DSBs. Following DSB induction, the chromatin surrounding the lesion is modified by the deposition of heterochromatin-specific histone variants and post-translational modifications (red) at the expense of active marks (green). This contributes to silence transcription in the vicinity of the DSB. For simplicity, all chromatin marks are represented on a single nucleosome flanking a DSB. Most of the players that promote the recovery of the pre-existing marks after completion of DSB repair are still unknown, as indicated by the question marks. White ovals and rectangles represent histone modifying enzymes and histone chaperone/remodeler, respectively.