Table 2.
Characteristics of children and adolescents with non-acquired GHD (idiopathic GHD [IGHD] plus congenital GHD [cGHD]) at diagnosis).
| hGH available | pit-Hgh National Institution | pit-hGH commercial | r-hGH | |||||
|---|---|---|---|---|---|---|---|---|
| Qualifying hGH Test Maximum | < 5.0 ng/mL | <7 ng/mL | < 10 ng/mL | <7-8 ng/mL | ||||
| Author | Soyka et al. (1970) (Boston) (107) | Prader et al. (1970) (Zürich) (108) | Aceto et al. (1972) (USA) (109) | Ranke et al. (2018) (Tübingen) (110) | ||||
| Period -Years | <1970 | 1960-70 | <1972 | 1968- 87 | 1988-97 | 1998-07 | 2008-15 | |
| Parameter | ||||||||
| N | 15 | 7 | 52 | 87 | 112 | 331 | 45 | |
| Age (10th-90th centile) | yrs* | 8.7 | 8.0 | 11.2 | 8.2 (4.0-15.3) | 5.6 (2.9-11.9) | 6.7 (4.1-13.5) | 5.1 (2.5-10.6) |
| BoneAge | yrs* | na | 4.6 | 5.9 | 4.4 | 3.8 | 4.8 | 4.2 |
| Height (Ht) | SDSCA+ | -5.0 | -4.7 | -5.8 | -4.3 | -3.3 | -2.9 | -3.1 |
| Ht-velocity | cm/yr* | 2.8 | 2.5 | 3.4 | 4.7 | 4.9 | 5.1 | 5.3 |
| deltaHt | SDSCA+ | na | na | na | -0.14a | -0.23b | -0.04c | -0.23c |
| Test: maxGH | ng/mL* | <3.1 | na | <10 | 4.1 | 5.8 | 5.1 | 4.2 |
| IGF-I | SDSCA+ | na | na | na | -2.9 | -3.2 | -2.6 | -4.8 |
| IGFBP-3 | SDSCA+ | na | na | na | na | -2.7 | -1.0 | -3.4 |
| Isolated GHD | % | na | na | na | 40 | 63 | 77 | 82 |
*Median; +Mean; comm, commercial production; an = 32; bn = 52; cn = 214; dn = 36; na, not available.