Skip to main content
. 2021 Sep 1;12:720419. doi: 10.3389/fendo.2021.720419

Table 3.

Examples of height in children with non-acquired GHD: start GH, puberty onset (spontaneous vs. induced), near adult height (NAH).

Ranke et al. (1997) [KIGS] (163) Thomas et al. (2001) [Belgium] (164) Maghnie et al. (2006) [Italy] (165)
male female male female male female
Pub spon Pub ind. Pub spon Pub ind. Pub spon Pub ind. Pub spon Pub ind. Pub spon Pub ind. Pub spon Pub ind.
N 66 51 64 14 25 7 24 5 26 31 31 18
GH start median mean median
maxGH to tests ng/mL <10 <10 <10
Age yr 10.5 9.9 9.9 6.8 12.4 14.4 10.6 11.5 8.0 6.5 7.7 10.5
Ht SDSCA -2.7 -2.8 -2.9 -2.7 -2.7 -2.9 -2.7 -2.9 -3.0 -3.0 -2.6 -3.6
targtHt SDS -0.4 -0.7 -0.1 -0.4 -0.8 -0.1 -0.8 -0.1 -0.4 -0.5 -0.6 -0.4
GH dose IU/kg 0.57 0.5-0.7 0.60
GH (inj./wk) r-hGH (2-7) r-hGH (7) r-hGH (5-7)
Pub start
Age yr 13.8 14.9 12.9 13.7 13.3 17.2 11.8 14.9 13.4 14.9 12.6 13.5
Ht SDSCA -1.6 -1.3 -1.4 -1.0 -1.9 -1.4 -1.9 -1.4 -1.5 -2.3 -1.8 -2.3
Pub Ht gain cm 22.5 19.6 15.0 10.4 27.5 17.1 22.2 9.6 22.8 20.5 17.1 16.5
At NAH
Age yr 17.8 19.2 16.0 17.0 19.1 21.0 16.2 18.5 17.6 19.4 16.5 20.0
Ht SDSCA -1.3 -0.5 -1.2 -0.9 -0.8 -0.3 -0.8 -0.3 -0.9 -0.7 -0.4 -0.8
Ht - Ht GHstart SDSCA 1.3 2.3 1.7 1.7 1.9 2.6 1.9 2.6 2.1 2.3 2.3 1.7
Ht - Ht pub ons. SDSCA 0.3 0.7 0.1 -0.1 0.0 0.1 0.0 0.1 0.6 0.6 1.4 1.5

Ht, height; Pub, puberty; spont., spontaneous; ind., induced; ons., onset.