Table 7.
Patterns of genes expression revealed by the transcriptomic analyses for different pathways of interest.
| Pathways | Effect of the genotype | Effect of the V diet | ||
|---|---|---|---|---|
| R23h | AB1h | A22h | ||
| ENERGY PRODUCTION | ||||
| TCA cycle, respiratory chain | AB1h-R23h>A22h | ns (60/76) | ns (54/76) | down (62/76) |
| LIPID METABOLISM | ||||
| Cholesterol metabolism | AB1h>A22h | up (15/17) | up (15/17) | ns/down (15/17) |
| LC-PUFA biosynthesis | AB1h-R23h>A22h | up (4/6) | up (5/6) | ns/down (5/6) |
| Lipogenesis | AB1h-R23h>A22h | up (4/4) | up (4/4) | up/ns (4/4) |
| Triglycerides biosynthesis | AB1h-R23h>A22h | up (2/4) | up (2/4) | up (3/4) |
| Prostaglandin biosynthesis | AB1h>A22h | ns (2/2) | down (1/2) | down (2/2) |
| β-oxidation | AB1h-R23h>A22h | ns (10/12) | ns (10/12) | ns/down (10/12) |
| PROTEIN CATABOLISM | AB1h>A22h | ns (23/26) | ns (22/26) | down (21/26) |
| RIBOSOMAL PROTEIN | R23h-AB1h>A22h | ns (32/59) | ns (45/59) | down (53/59) |
| AA: | ||||
| Catabolic pathways | R23h-AB1h>A22h | ns/up (9/11) | ns/up (11 /11) | ns/down (10/11) |
| (Tryptophan, L-Leucine, L-Lysine, L-Phénylalanine) | ||||
| Transaminases | R23h-AB1h>A22h | ns (10/10) | ns (7/10) | down (8/10) |
| Glycine and serine metabolism | R23h-AB1h>A22h | up (8/8) | up (7/8) | ns (6/8) |
| Sulfur amino metabolism | R23h-AB1h>A22h | up (4/9) | up (6/9) | down/ns (6/9) |
| L-arginine biosynthesis | R23h-AB1h>A22h | ns (4/5) | ns (4/5) | down (4/5) |
| CARBOHYDRATE METABOLISM | No specific pattern | – | – | – |
| IMMUNITY | No specific pattern | – | – | – |
| (Complement pathways, inflammatory response, | ||||
| cytokine activity, T-cell activation and apoptosis) | ||||
The “Effect of the genotype” displays the differential expression between lines when they were fed the complete plant-based diet (V). The “Effect of the V diet” displays to the effect of the complete plant-based diet for each isogenic line (with “up” = gene was up-regulated when fed the V diet in comparison to the control M diet; “down” = gene was down-regulated when fed the V diet in comparison to the control M diet; “ns” = gene expression was not significantly modified when fed the V diet in comparison to the control M diet., and diet., and “(x/y)” refers to the number of genes included.