Table 3.
Univariate and multivariate cox regression analysis of factors associated with cancer-specific survival.
| Characteristics | Univariate analysis | Multivariate (model 1 NLR) | Multivariate (model 2 SII) | Multivariate (model 3 SIRI) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95%CI | P | HR | 95%CI | P | HR | 95%CI | P | HR | 95%CI | P | ||
| Gender: Male/Female | 0.447 | 0.292-0.685 | <0.001 | 0.697 | 0.448-1.084 | 0.109 | 0.657 | 0.422-1.021 | 0.062 | 0.738 | 0.470-1.159 | 0.738 | |
| Age | 0.070 | 0.039 | 0.145 | ||||||||||
| <60y | Ref | Ref | Ref | Ref | |||||||||
| 60-70y | 1.501 | 0.933-2.414 | 0.094 | 1.486 | 0.920-2.401 | 0.105 | 1.555 | 0.959-2.521 | 0.073 | 1.412 | 0.876-2.276 | 0.156 | |
| ≧̸70y | 1.914 | 1.073-3.413 | 0.028 | 1.642 | 0.918-2.939 | 0.095 | 2.071 | 1.157-3.706 | 0.014 | 1.744 | 0.974-3.124 | 0.061 | |
| Smoking history (No/Yes) | 1.211 | 0.722-2.031 | 0.468 | ||||||||||
| Location (Left/Right) | 0.941 | 0.613-1.443 | 0.779 | ||||||||||
| T stage (T1/T2a) | 3.957 | 2.602-6.019 | <0.001 | 1.606 | 1.034-2.493 | 0.035 | 1.777 | 1.151-2.743 | 0.010 | 1.755 | 1.134-2.716 | 0.012 | |
| Histological pattern | <0.001 | <0.001 | <0.001 | <0.001 | |||||||||
| SMPN | Ref | Ref | Ref | Ref | |||||||||
| SMPM | 5.019 | 3.078-8.185 | <0.001 | 2.636 | 1.582-4.392 | <0.001 | 2.568 | 1.544-4.271 | <0.001 | 2.504 | 1.505-4.165 | <0.001 | |
| SMPP | 9.946 | 5.476-18.064 | <0.001 | 3.781 | 2.001-7.146 | <0.001 | 3.983 | 2.116-7.496 | <0.001 | 3.679 | 1.954-6.930 | <0.001 | |
| LVI (No/Yes) | 1.506 | 0.369-6.137 | 0.568 | ||||||||||
| Radiologic features (Subsolid/Solid) | 3.874 | 2.346-6.398 | <0.001 | 6.827 | 2.375-19.625 | <0.001 | 6.845 | 2.389-19.617 | <0.001 | 6.896 | 2.410-19.735 | <0.001 | |
| NLR (Low/High) | 4.390 | 2.891-6.666 | <0.001 | 3.756 | 2.446-5.766 | <0.001 | NI | NI | |||||
| SII (Low/High) | 3.609 | 2.358-5.522 | <0.001 | NI | 3.545 | 2.306-5.449 | <0.001 | NI | |||||
| SIRI (Low/High) | 2.965 | 1.957-4.494 | <0.001 | NI | NI | 2.281 | 1.477-3.524 | <0.001 | |||||
SMPP, solid/micropapillary-predominant; SMPM, solid/micropapillary-minor; SMPN, solid/micropapillary-negative; LVI, lymphovascular invasion; NLR, neutrophil-to-lymphocyte ratio; SII, systemic immune-inflammation index; SIRI, systemic inflammation response index; NI, not included in the multivariate model; Ref, reference, HR, hazard ratio, CI, confidence interval.