Table 3.

Associations of a One-Interquartile Range (3-Unit) Decrement in SPPB with Incident Acute Decompensated Hospitalized Heart Failure Stratified by Selected Baseline Characteristics.

	N	No. Events	HR (95% CI)a	p-interaction
Total Sample	5253	302	1.41 (1.23–1.62)
Age				0.096
< 80 Years	2681	83	1.45 (1.09–1.92)
≥ 80 Years	2572	219	1.40 (1.20–1.63)
BMI				0.749
< 30 kg/m2	3613	208	1.41 (1.20–1.66)
≥ 30 kg/m2	1640	94	1.41 (1.10–1.80)
Reynolds Risk Score*				0.004
< 9.9	2129	83	1.48 (1.12–1.95)
≥ 9.9	2144	169	1.37 (1.14–1.64)
MVPA				0.119
< 45 min/day	2621	215	1.29 (1.10–1.52)
≥ 45 min/day	2632	87	1.60 (1.23–2.09)
Diabetes				0.633
Without	4181	217	1.44 (1.23–1.69)
With	1072	85	1.32 (1.02–1.71)
Hypertension				0.890
Without	1498	61	1.30 (0.96–1.76)
With	3755	241	1.45 (1.25–1.69)
Race/Ethnicity				0.513
White	2550	202	1.43 (1.22–1.68)
Black	1784	75	1.50 (1.12–2.01)
Hispanic	919	25	1.03 (0.61–1.72)

Abbreviations: HR = hazard ratio; CI = confidence interval; BMI = body mass index; MVPA = moderate-to-vigorous physical activity.

Reynolds risk score and MVPA were split at the median.

^aModel 3 (Table 2) was used for all hazard ratios; adjusted for age, race/ethnicity (except for race/ethnicity strata), education, smoking status, alcohol use, diabetes (except for diabetes strata), hypertension (except for hypertension strata), COPD, osteoarthritis, depression, and BMI.

^⁎10-Year predicted probability (%) of a clinical CVD event.