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. 2021 Sep 10;71:103562. doi: 10.1016/j.ebiom.2021.103562

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© 2021 The Authors. Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1. — Human (top) and Old World monkey (OWM) (bottom) IgM (left) and IgG (middle) binding and complement-dependent cytotoxicity (CDC, at 25% serum concentration) (right) to wild-type (WT), GTKO, and TKO pig PBMCs. Results are expressed as mean ± SEM. (*p < 0.05, **p < 0.01; N.S. = not significant). On the y axis, the dotted line represents cut-off value of binding (relative GM: IgM 1.2, IgG 1.1), below which there is no binding. For CDC on the y axis, the dotted line represents cut-off value of cytotoxicity (6.4%), below which there is no cytotoxicity. (Note the difference in scale on the y axis between IgM and IgG.) (Reprinted with permission from Yamamoto T, et al. 2020¹⁸).