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Example of a spontaneous increase in serum creatinine in a baboon with a life-supporting pig kidney transplant (with nephrectomy of the native kidneys at the time of pig kidney transplantation). The rapid reduction in creatinine to normal (human) levels was associated solely with an i.v. infusion of normal saline (arrow). A renal biospy at the time showed no features of rejection. (Reprinted with permission from Iwase H, et al, 201865).
