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Carbohydrate xenoantigens that have been deleted in genetically-engineered pigs.
| Carbohydrate (Abbreviation) | Responsible enzyme | Gene-knockout pig |
|---|---|---|
|
1. Galactose-α1,3-galactose (Gal) |
α1,3-galactosyltransferase | GTKO |
| 2. N-glycolylneuraminic acid (Neu5Gc) |
Cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) |
CMAH-KO |
| 3. Sda | β-1,4N-acetylgalactosaminyltransferase | β4GalNT2-KO |
