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. 2021 Sep 10;71:103562. doi: 10.1016/j.ebiom.2021.103562

Table 4.

A representative immunosuppressive, anti-inflammatory, and adjunctive drug regimen used in pig-to-baboon kidney transplantation experiments at our center.

Agent Dose (duration)
Induction
Thymoglobulin (ATG) (Genzyme, Cambridge, MA) 5 mg/kg i.v. (days -3 and -1) (to reduce the CD3+T cell count to <500/mm3)

Anti-CD20mAb (rituximab) (Genentech, South San Francisco, CA)
10 mg/kg i.v. (day -2)

C1-esterase inhibitor (Berinert, CSL Behring, King of Prussia, PA)
17.5 U/kg i.v. (days 0, 1, 7 and 14)
Maintenance

Anti-CD40 monoclonal antibody (mAb) (2C10R4, a chimeric rhesus IgG4) (NIH NHP Resource Center, Boston, MA)
50 mg/kg (days -1, 0, 4, 7, 14, and weekly)
Rapamycin (Rapa) (LC Laboratories, Woburn, MA) 0.01-0.04 mg/kg i.m. × 2/d (target trough 6-10 ng/ml), beginning on day -4.

Methylprednisolone (Astellas, Deerfield, IL)

5 mg/kg/d on day 0, tapering to 0.125 mg/kg/d by day 7.
Anti-inflammatory

Etanercept (TNF-α antagonist) (Amgen, Thousand Oaks, CA)

1 mg/kg (day 0), 0.5 mg/kg i.v. (days 3, 7, 10)
Adjunctive
Aspirin (Bayer, Deland, FL)
40 mg p.o. (alternate days), beginning on day 4.

Low molecular weight heparin (LMWH) (Eisai,
Woodcliff Lake, NJ)
700 IU/d s.c., beginning of day 1.
Erythropoietin (Amgen) 500 U i.v. weekly, beginning on day -4
Ganciclovir (Genentech) 5 mg/kg/d i.v., from day -4 to day 14 and when the baboon is sedated for blood draws (x2 weekly).

Valganciclovir (Genentech)

15 mg/kg/d p.o., beginning on day 15

Sulfamethoxazole and trimethoprim (Teva, North Wales, PA)

10 mg/kg i.v. daily, on days 4-14
Sulfamethoxazole and trimethoprim oral
suspension (Akorn, Lake Forest, IL)
75 mg/m2 p.o x2/day. x3 weekly, beginning on day 15.