Table 4.
Agent | Dose (duration) |
---|---|
Induction | |
Thymoglobulin (ATG) (Genzyme, Cambridge, MA) | 5 mg/kg i.v. (days -3 and -1) (to reduce the CD3+T cell count to <500/mm3) |
Anti-CD20mAb (rituximab) (Genentech, South San Francisco, CA) |
10 mg/kg i.v. (day -2) |
C1-esterase inhibitor (Berinert, CSL Behring, King of Prussia, PA) |
17.5 U/kg i.v. (days 0, 1, 7 and 14) |
Maintenance | |
Anti-CD40 monoclonal antibody (mAb) (2C10R4, a chimeric rhesus IgG4) (NIH NHP Resource Center, Boston, MA) |
50 mg/kg (days -1, 0, 4, 7, 14, and weekly) |
Rapamycin (Rapa) (LC Laboratories, Woburn, MA) | 0.01-0.04 mg/kg i.m. × 2/d (target trough 6-10 ng/ml), beginning on day -4. |
Methylprednisolone (Astellas, Deerfield, IL) |
5 mg/kg/d on day 0, tapering to 0.125 mg/kg/d by day 7. |
Anti-inflammatory | |
Etanercept (TNF-α antagonist) (Amgen, Thousand Oaks, CA) |
1 mg/kg (day 0), 0.5 mg/kg i.v. (days 3, 7, 10) |
Adjunctive | |
Aspirin (Bayer, Deland, FL) |
40 mg p.o. (alternate days), beginning on day 4. |
Low molecular weight heparin (LMWH) (Eisai, Woodcliff Lake, NJ) |
700 IU/d s.c., beginning of day 1. |
Erythropoietin (Amgen) | 500 U i.v. weekly, beginning on day -4 |
Ganciclovir (Genentech) | 5 mg/kg/d i.v., from day -4 to day 14 and when the baboon is sedated for blood draws (x2 weekly). |
Valganciclovir (Genentech) |
15 mg/kg/d p.o., beginning on day 15 |
Sulfamethoxazole and trimethoprim (Teva, North Wales, PA) |
10 mg/kg i.v. daily, on days 4-14 |
Sulfamethoxazole and trimethoprim oral suspension (Akorn, Lake Forest, IL) |
75 mg/m2 p.o x2/day. x3 weekly, beginning on day 15. |