TABLE 3.

Association between methylation levels in mQTL‐associated CpGs and Frailty Index in SATSA

CpG site	Estimate	SE	p	p Bonferroni	CHR	BP	UCSC Ref Gene	Associated variant
cg20614157	9.04E−04	0.0003	<0.001	0.037	6	31980845	TNXB,TNXA,STK19	rs17421133, rs2077116, rs17207951, rs2857009, rs2071295, rs17201588, rs6902493, rs41268896
cg19376858	8.38E−04	0.0003	0.008	0.084	6	31980856	TNXB,TNXA,STK19	rs6449, rs3020644, rs9267806, rs4713506, rs6941112, rs4713505, rs9267803, rs6463, rs9267802, rs4151657, rs8111, rs17421133, rs2280774, rs6415128, rs2894250, rs2228628, rs2857009, rs2077116, rs6902493, rs17201588
cg15321244	−2.23E−02	0.0088	0.011	1	6	32729643	HLA‐DQB2	rs9275987, rs2261566
cg23928032	−9.75E−03	0.0038	0.011	1	6	31964391	C4B.C4A	rs9267806, rs4713506, rs4713505, rs9267803, rs6463, rs9267802, rs8111, rs17421133, rs2228628, rs2857009, rs2077116, rs6902493, rs17201588, rs17207951, rs2239689, rs28361052, rs2071295, rs17421624, rs41268896, rs2071293
cg01937212	−1.43E−02	0.0062	0.020	1	6	32295097	C6orf10	rs9268301, rs9368714, rs2076540, rs2746115, rs2143466, rs761187, rs9268129, rs471081, rs6929776, rs9348880, rs2022533, rs6457544, rs6457543, rs565571, rs9366793, rs9394087, rs9268141, rs546857, rs477005, rs557539
cg11391305	−1.43E−02	0.007	0.042	1	6	32731438	HLA‐DQB2	rs9275987

Abbreviations: BP = Genomic position (b37);CHR = chromosome; mQTL = methylation quantitative trait loci; SATSA = Swedish Adoption/Twin Study of Aging; SE = standard error.

^*If >20 associated variants, the first 20 with lowest p‐values are included (see Table S9 for full results).