TABLE 1.
Population characteristics, baseline disease prevalence, and incident morbidity and mortality
| All | Male | Female | |
|---|---|---|---|
| n | 440,185 (100.0%) | 201,258 (45.7%) | 238,927 (54.3%) |
| Deaths | 18,027 (4.1%) | 10,887 (5.4%) | 7140 (3.0%) |
| Baseline Dementia | 199 (<0.05%) | 108 (0.1%) | 91 (<0.05%) |
| Baseline Vascular Disease | 15,886 (3.6%) | 11,286 (5.6%) | 4600 (1.9%) |
| Baseline Osteoporosis | 2462 (0.6%) | 730 (0.4%) | 1732 (0.7%) |
| Baseline Diabetes | 21,336 (4.8%) | 13,566 (6.7%) | 7770 (3.3%) |
| Baseline Cancer | 23,681 (5.4%) | 8771 (4.4%) | 14,910 (6.2%) |
| Incident Dementia | 2168 (0.5%) | 1200 (0.6%) | 968 (0.4%) |
| Incident Vascular Disease | 12,002 (2.7%) | 7916 (3.9%) | 4086 (1.7%) |
| Incident Osteoporosis | 7130 (1.6%) | 1162 (0.6%) | 5968 (2.5%) |
| Incident Diabetes | 9597 (2.2%) | 5531 (2.7%) | 4066 (1.7%) |
| Incident Cancer | 26,176 (5.9%) | 13,643 (6.8%) | 12,533 (5.2%) |
| Mortality Follow‐up (years) | 11.0 ± 1.5 | 10.9 ± 1.7 | 11.1 ± 1.4 |
| Morbidity Follow‐up (years) | 10.5 ± 1.7 | 10.5 ± 1.8 | 10.6 ± 1.5 |
| Age (years) | 57.3 ± 8.0 | 57.5 ± 8.1 | 57.1 ± 7.9 |
| Age Quartile 1 | 37.4–50.7 | 37.4–50.7 | 39.7–50.5 |
| Age Quartile 2 | 50.5–58.7 | 50.7–58.7 | 50.5–58.0 |
| Age Quartile 3 | 58.0–64.1 | 58.7–64.1 | 58.0–63.4 |
| Age Quartile 4 | 63.4–73.7 | 64.1–73.7 | 63.4–71.1 |
| IGF‐1 (ng/ml) | 163.6 ± 43.4 | 167.7 ± 42.4 | 160.2 ± 44.0 |
| IGF‐1 Quintile 1 | 11.1–132.8 | 14.6–132.8 | 11.1–122.5 |
| IGF‐1 Quintile 2 | 122.6–156.7 | 132.8–156.7 | 122.6–147.4 |
| IGF‐1 Quintile 3 | 147.5–176.3 | 156.7–176.3 | 147.5–169.3 |
| IGF‐1 Quintile 4 | 169.3–199.4 | 176.3–199.4 | 169.3–194.6 |
| IGF‐1 Quintile 5 | 194.6–969.6 | 199.4–969.6 | 194.6–956.9 |