TABLE 3.
Composite and mortality epigenetic clocks
| Clock | No. CpGs | Method used to obtain CpGs | No. of samples in training | Reference |
|---|---|---|---|---|
| PhenoAge | 513 | Elastic net | 9,926 | Levine et al. (2018) |
| GrimAge | 1,113 | Elastic net | 1,731 | Lu, Quach, et al. (2019) |
| Zhang Mortality Clock | 10 | LASSO Cox regression | 548 | Zhang, Wilson, et al. (2017) |
| DunedinPoAm | 46 | Elastic net | 810 | Belsky et al. (2020) |
| Telomere Clock | 140 | Elastic net | 2,256 | Lu, Seeboth, et al. (2019) |
All clocks in this table are composite clocks, i.e. CpGs that correlate with physiological or cellular ageing are used to create a biological age predictor (except the Zhang Mortality Clock, where mortality data were directly regressed on DNAm).