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. 2021 Aug 3;5(9):e10530. doi: 10.1002/jbm4.10530

Fig. 1.

Fig. 1

Anti‐TGF‐β antibody 1D11 induces robust, dose‐related increases in lumbar bone (l6) trabecular parameters and strength mice with osteogenesis imperfecta (OI). (A) Bone volume, (B) trabecular separation, (C) trabecular number, (D) trabecular thickness, and trabecular total mineral density all via μCT imaging, and (E) peak force measured via biomechanical compression test of OI and WT mice. μCT lumbar n = 10, 9, 9, 10, 9, and 10 for group 1–6, respectively. Biomechanics lumbar n = 10, 9, 9, 10, 10, and 10 for groups 1–6, respectively. Mean ± SD and asterisk(s) denote statistically significant difference compared with OI 13C4, 10 mg/kg. a0.01 < p < 0.05. b0.001 < p < 0.01. c0.0001 < p < 0.001. d p < 0.0001. BV/TV = bone volume fraction; Tb.N = trabecular number; Tb.Sp = trabecular spacing; Tb.Th = trabecular thickness.