Table 1.
Effect of Treatment on Cortical Bone and Strength in the Femur of WT and OI Mice
| Property | WT 13C4 | OI 13C4 | OI 1D11 | OI 1D11 | OI 1D11 | OI 1D11 |
|---|---|---|---|---|---|---|
| 10 mg/kg | 10 mg/kg | 0.5 mg/kg | 1 mg/kg | 5 mg/kg | 10 mg/kg | |
| Cortical (diaphysis) | ||||||
| Cortical bone area (mm2) | 0.744 ± 0.030 c | 0.654 ± 0.042 | 0.671 ± 0.036 | 0.682 ± 0.020 | 0.686 ± 0.037 | 0.670 ± 0.044 |
| Total cross‐sectional area (mm2) | 1.70 ± 0.068 c | 1.40 ± 0.080 | 1.37 ± 0.073 | 1.39 ± 0.051 | 1.40 ± 0.055 | 1.39 ± 0.089 |
| Minimum moment of inertia (mm4) | 0.110 ± 0.011 c | 0.080 ± 0.008 | 0.078 ± 0.008 | 0.081 ± 0.007 | 0.081 ± 0.008 | 0.079 ± 0.009 |
| Average cortical thickness (mm) | 0.163 ± 0.005 b | 0.153 ± 0.007 | 0.160 ± 0.007 | 0.161 ± 0.006 | 0.162 ± 0.004 a | 0.159 ± 0.010 |
| Biomechanical | ||||||
| Stiffness (N/mm) | 93.0 ± 18.6 | 96.8 ± 13.5 | 101 ± 13.4 | 110 ± 7.99 | 112 ± 11.7 | 106 ± 12.3 |
| Modulus (GPa) | 9.03 ± 1.70 c | 12.9 ± 1.46 | 13.8 ± 0.914 | 14.6 ± 0.832 b | 14.8 ± 0.989 b | 14.4 ± 0.594 a |
| Yield force (N) | 12.2 ± 1.49 | 11.7 ± 1.29 | 13.0 ± 1.49 | 13.5 ± 1.02 a | 13.5 ± 1.02 a | 13.5 ± 1.40 a |
| Yield strength (MPa) | 138 ± 20.9 b | 165 ± 13.7 | 187 ± 17.7 a | 191 ± 17.5 b | 189 ± 12.9 a | 195 ± 21.1 b |
| Work‐to‐fracture (N*mm) | 8.86 ± 2.19 c | 4.23 ± 0.821 | 3.89 ± 0.612 | 4.05 ± 0.787 | 3.77 ± 0.928 | 3.71 ± 0.926 |
Mean ± SD and asterisk(s) denote statistically significant difference compared with OI 13C4, 10 mg/kg.
mg HA = mg hydroxyapatite; OI = osteogenesis imperfecta.
a
0.01 < p < 0.05.
b
0.001 < p < 0.01.
c
p < 0.0001.