Table 2.

Effect of Treatment on Cortical Bone and Biomechanics in the Femur of WT and OI Mice

Property	WT 13C4	OI 13C4	OI 1D11	OI 1D11	OI 1D11	OI 1D11
	5 mg/kg	5 mg/kg	5 mg/kg	5 mg/kg	5 mg/kg	5 mg/kg
	3 × wk	3 × wk	3 × wk	1 × wk	1 × 2 wk	1 × 4 wk
Cortical (Diaphysis)
Cortical bone area (mm2)	0.700 ± 0.047	0.645 ± 0.027	0.719 ± 0.018 a	0.702 ± 0.032 a	0.704 ± 0.031 a	0.690 ± 0.050
Total cross‐sectional area (mm2)	1.72 ± 0.098 c	1.43 ± 0.040	1.49 ± 0.031	1.45 ± 0.084	1.50 ± 0.063	1.44 ± 0.076
Minimum moment of inertia (mm4)	0.106 ± 0.012 c	0.081 ± 0.004	0.089 ± 0.004	0.083 ± 0.008	0.089 ± 0.008	0.085 ± 0.008
Average cortical thickness (mm)	0.151 ± 0.009	0.151 ± 0.010	0.158 ± 0.006	0.154 ± 0.010	0.161 ± 0.005	0.158 ± 0.005
Biomechanical
Stiffness (N/mm)	90.1 ± 12.5	90.3 ± 13.8	109 ± 18.4	101 ± 9.15	106 ± 7.29	101 ± 16.4
Modulus (GPa)	9.14 ± 1.41 a	11.9 ± 1.80	13.2 ± 2.22	13.0 ± 1.26	12.9 ± 1.39	12.7 ± 1.99
Yield force (N)	10.8 ± 2.28	11.2 ± 1.47	14.7 ± 1.12 a	13.3 ± 1.06	14.7 ± 1.19 b	13.2 ± 2.46
Yield strength (MPa)	126 ± 21.1 a	156 ± 21.5	195 ± 19.9 a	185 ± 10.7 a	191 ± 17.3 a	180 ± 23.7
Work‐to‐fracture (N*mm)	8.88 ± 2.33 c	3.42 ± 0.85	3.83 ± 0.437	3.36 ± 0.873	4.10 ± 0.892	3.67 ± 1.26

Mean ± SD and asterisk(s) denote statistically significant difference compared with OI 13C4 3 × wk, 5 mg/kg, ip.

mg HA = mg hydroxyapatite; OI = osteogenesis imperfecta.

^a 0.01 < p < 0.05.

^b 0.001 < p < 0.01.

^c p < 0.0001.