Table 2.

Clinical and demographic data of pregnant women with pemphigus.

Authorsa	Number of women	Diagnosis before pregnancy	Diagnosis during pregnancy	Disease	Age at onset (years)	Week of gestation at the onset or worsening	Worsening during pregnancy	Improvement during pregnancy	Stable during pregnancy	Worsening in postpartum	Newborn with bullous lesions	Treatment
Lake et al.	1	X		PV	24	NA			X			C/MPM/AZA/IVIG/RTX
	1	X		PV	19	NA			X			C/MPM/IVIG/RTX
Rangel	1		X	PV	24	11	X			X		C/RTX
Elmuradi et al.	1	X		PV	33	24	X					C/MPM/IVIG/RTX
Çayirli et al.	1	X		PV	NA	18	X					C/AZA
Salzberg et al.	1		X	PV	34	6	X					C
Kodagali et al.	1	X		PV	NA	NA					X	C
Solís-Arias et al.	1	X		PV	21	3	X			X		C
Itsukaichi et al.	1	X		PV	34	NA	X			X	X
Ibrahim et al.	1		X	PV	23	22	X				X	C/IVIG
Lorente Lavirgen et al.	1	X		PF	33	24	X				X	C
Drenovska et al.	1		X	PV	27	NA			X	X		C
	1	X		PV	24				X			C
Galarza et al.	1		X	PF	36	17						C
Gushi et al.	1	X		PV	32	NA			X		X	C
Lehman et al.	1	X		PV	32	NA			X
Amer et al.	1	X		PV	NA	NA			X			C
Ugajin et al.	1	X		PV	30	NA	X			X		C
Bonifazi et al.	1		X	PV	NA	NA				PV onset 6 months post- partum	X
Fenniche et al.	1	X		PV	29	12		X		X		C
López-Jornet et al.	1		X	PV	32	20	X					C
Shieh et al.	1		X	PV	29	16	X				X	C
Okubo et al.	1		X	PV	24	18		X		X		C
Hirsch et al.	1	X		PF	23	NA					X
Parlowsky et al.	1	X		PV	NA	NA	X			X
Campo-Voegeli et al.	1		X	PV	35	8	X				X	C
Kalayciyan et al.	1		X	PV	31	32						C/AZA
	1		X	PV	33	8						C
	1		X	PV	32	10						C
	1		X	PV	30	4						C
Muhammad et al.	1		X	PV	28	8	X					C
Masson et al.	1	X		PV	38	12	X					C
Avalos-Díaz et al.	1	X		PF	20	NA	X				X	C
Piontek et al.	1	X		PV	29	12	X					C
Fainaru et al.	1	X		PV	32	13	X					C
Kanwar et al.	1		X	PV	33	24	X				X	C
Hern et al.	1		X	PV	32	14	X					C
	1	X		PV	33	14	X					Symptomatic treatment
Chowdhury et al.	1	X		PV	31	18			X		X	C
Virgili et al.	1		X	PV	27	26	X					C
Tope et al.	1	X		PV	27	NA		X			X	C
Goldberg et al.	1	X		PV	21	28	X					C
Kanwar et al.	1		X	PV	21	6			X			C
Moncada et al.	1	X		PV	28	16			X	X		C
Kaufman et al.	1		X	PF	27	16	X					C
Eyre et al.	1	X		PF	37	NA	X					C
Hup et al.	1	X		PV	20	NA			X
Merlob et al.	1	X		PV	24	NA			X		X	C
Ross et al.	1		X	PV	19	13	X				Fetal death	C/AZA
Wasserstrum et al.	1	X		PV	30	20	X				Fetal death	C/AZA
Green et al.	1	X		PV	36	28	X				Fetal death	C
Moncada et al.	1		X	PV	18	14	X					C
Honeyman et al.	1		X	PV	25	32	X					C
			X	PV	29	NA	NA			X (post- miscarriage)	Miscarriage
			X	PV	33	16	X					C
Terpstra et al.	1		X	PV	23	12	X				Fetal death	C/DAPSONE
Stanoeva et al.	1	X		PV	33	13	X					C
	1		X	PV	28	20			X	X		C
	1		X	PV	29	20			X			C

PV, Pemphigus Vulgaris; PF, Pemphigus Foliaceus; NA, data Not Available; C, Corticosteroids; MPM, Mycophenolate Mofetil; AZA, Azathioprine; RTX, Rituximab; IVIG, Intravenous Immunoglobulin.

^aBibliographic references are available as supplementary material (Appendix A).