TABLE 1.

PASC fatigue assessment recommendations

#	Statement
1	Patients should be assessed for fatigue patterns throughout their normal day to guide activity recommendations.
1a	Patients should be assessed for their responses to initiating and escalating activity on their fatigue.
1b	Patients should be evaluated for changes in daily functioning and activity levels.
1c	Patients' physical functioning and endurance should be assessed to inform activity and therapy recommendations. (Examples of tests that can be chosen based on an individual's activity tolerance: 30 s sit to stand55; 2‐min step (seated or standing)56; 6 min walk test57; 10 m walk test58).
2	Clinicians should assess for changes in activities of daily living, independent activities of daily living, school, work, and avocational (ie, hobbies)
3	A full patient history with review of preexisting conditions should be conducted
4	Patients should be evaluated for conditions that may exacerbate fatigue symptoms and warrant further testing and potential subspecialty referral (see Table 2). Particular areas include: Sleep Mood, including anxiety, depression and PTSD. Note: Patients often report dissatisfaction with their care because of their persistent symptoms being attributed to psychological factors. It is important to note that mood disorders may be secondary to persistent medical issues or one of many factors leading to fatigue. Cardiopulmonary Autoimmune Endocrine
5	A medication review should be conducted to investigate medications that may be contributing to fatigue. Of note, antihistamine, anticholinergic, and antidepressant/anxiolytic medications can contribute to fatigue in patients with PASC.
6	The following basic lab workup should be considered in new patients or those without lab workup in the 3 months before visit including complete blood count with differential, chemistries including renal and hepatic function tests, thyroid stimulating hormone, c‐reactive protein or erythrocyte sedimentation rate, and creatinine kinase. Other laboratory tests may be considered based on the results of these tests or if there is specific concern for comorbid conditions as outlined in Table 2.

Abbreviations: PASC, postacute sequelae of SARS‐CoV‐2 infection; PTSD, posttraumatic stress disorder.