TABLE 1.

(A) The amino acid sequences of NTH and the peptides used in this study. (B) Quantitative assessment, using TM‐Align server, of hACE2 NTH Structural Similarity with peptides from RCSB (https://www.rcsb.org/) selected on the basis as described in the Results. The reference protein was NTH of ACE2. The descriptions are from (https://www.rcsb.org/)

Panel A
Structure	Amino acid sequence
NTH	STIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTN
2K6O (LL‐37)	LLGD FFRKSKEKIGKEFKRIVQRIKDFLRNLVP RTES
2D2P	HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNKX
2KB8	KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY
2L63	HADGSFSDEMNTILDNLAARDFINWLIQTKITD

Panel B
Structure	Peptide length	TM‐score	RMSD (Å)	Aligned length	Description
N‐terminal helix	35	1	0	35	N‐terminal helix of ACE2 (from 6LZG)
Strict search
2K6O (LL‐37)	37	0.68037	1.5	32	Anti‐microbial peptide
2D2P	38	0.56736	1.62	34	Pituitary adenylate cyclase activating polypeptide‐38
1GOE	42	0.51713	2.61	33	Corticotropin releasing hormone
1G09	42	0.52615	2.61	33	Corticotropin releasing hormone
2RMY	34	0.55258	1.52	27	N‐BAR domain
2KB8	37	0.54169	1.87	31	Amylin endocrine hormone
2N7I	37	0.59781	2.33	32	Prolactin receptor transmembrane domain
2LAT	37	0.69158	0.94	31	Human minimembrane protein Ost4
Relaxed search
2L63	33	0.44354	1.8	23	Glucagon‐like peptide‐2
6ITH	35	0.55154	1.64	32	Trans‐membrane domain of syndecan‐2
1R02	33	0.32949	2.35	22	Orexin‐A: Regulator of Appetite and Wakefulness
2L77	39	0.49377	2.2	25	PAP248‐286
2RND	34	0.51577	1.16	25	N‐terminal BAR peptide
5NAO	35	0.54347	1.41	28	TLR4 transmembrane domain (624–657)
6AHZ	35	0.59246	1.58	29	Polysialyltransferase Domain (PSTD) in Polysialyltransferase ST8siaIV
6F46	32	0.39864	1.43	22	Transmembrane helix of BclxL

Abbreviation: RMSD, root mean square deviation of the alignments.