Table 3.

Adverse events after the first and second doses of BNT162b2 vaccine in 390 pregnant women, according to the timing of vaccination during pregnancy

	First dose				Second dose
Adverse event	1st trimester (n = 76)	2nd trimester (n = 193)	3rd trimester (n = 121)	P	1st trimester (n = 52)	2nd trimester (n = 154)	3rd trimester (n = 184)	P
Local pain/swelling	73 (96.1)	181 (93.8)	104 (86.0)	0.02	48 (92.3)	140 (90.9)	172 (93.5)	0.68
Rash	0 (0)	2 (1.0)	1 (0.8)	0.68	0 (0)	2 (1.3)	3 (1.6)	0.65
Fever > 38°C	1 (1.3)	4 (2.1)	1 (0.8)	0.67	7 (13.5)	13 (8.4)	15 (8.2)	0.48
Fever ≥ 39°C	0 (0)	0 (0)	0 (0)	N/A	1 (1.9)	2 (1.3)	0 (0)	0.24
Severe fatigue	20 (26.3)	54 (28.0)	26 (21.5)	0.44	35 (67.3)	89 (57.8)	96 (52.2)	0.14
Arthralgia	0 (0)	4 (2.1)	0 (0)	0.13	2 (3.8)	10 (6.5)	4 (2.2)	0.14
Myalgia	5 (6.6)	14 (7.3)	4 (3.3)	0.34	15 (28.8)	38 (24.7)	41 (22.3)	0.61
Axillary lymphadenopathy	0 (0)	0 (0)	1 (0.8)	0.33	3 (5.8)	1 (0.6)	4 (2.2)	0.08
Paresthesia	2 (2.6)	5 (2.6)	2 (1.7)	0.85	3 (5.8)	9 (5.8)	6 (3.3)	0.48
Headache	5 (6.6)	8 (4.1)	5 (4.1)	0.66	2 (3.8)	21 (13.6)	17 (9.2)	0.11
Uterine contractions	0 (0)	2 (1.0)	3 (2.5)	0.29	0 (0)	2 (1.3)	23 (12.5)	< 0.001
Vaginal bleeding	1 (1.3)	0 (0)	0 (0)	0.13	2 (3.8)	2 (1.3)	2 (1.1)	0.34
Prelabor rupture of membranes	0 (0)	0 (0)	0 (0)	N/A	0 (0)	0 (0)	3 (1.6)	0.18

Data are given as n (%).

N/A, not applicable.