Figure 8.

miR-199-3p reverses the effect of circFLNA on glioblastoma cells. (A) miR-199-3p expression levels were upregulated following circFLNA knockdown in LN229 and A172 cells. (B) Expression levels of miR-199-3p in LN229 cells co-transfected with combinations of si-circFLNA, si-NC, miR-199-3p inhibitor and NC inhibitor. (C) Cell viability was detected using a Cell Counting Kit-8 assay. (D) Invasive ability was analyzed using a Transwell assay. Magnification, ×100; scale bar, 50 µm. Data are presented as the mean ± SD of 3 independent experiments. *P<0.05, **P<0.01, ***P<0.001; ^##P<0.01, ^###P<0.001. miR, microRNA; circFLNA, circular RNA filamin A; NC, negative control; si, small interfering RNA.