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. 2021 Sep 9;24(5):789. doi: 10.3892/mmr.2021.12429

Figure 2.

Figure 2.

INHBA overexpression promotes the invasion of lung cancer cells. (A) Western blotting and (B) semi-quantification of INHBA expression levels in five lung cancer cell lines and HBE cells. (C) Transient transfection of H1299 cells with the INHBA plasmid resulted in decreased expression levels of E-cadherin, and increased expression levels of N-cadherin, vimentin and Snail. (D) INHBA knockdown increased the expression levels of E-cadherin, and decreased the expression levels of N-cadherin, Snail and vimentin in A549 cells. (E) Cell invasion and migration were enhanced in H1299 cells transiently transfected with the INHBA plasmid. (F) Knockdown of INHBA decreased the invasive and migratory abilities of A549 cells. Original magnification, ×200. *P<0.05, **P<0.01, ***P<0.001. INHBA, inhibin βA; NC, negative control; si, small interfering; HBE, human bronchial epithelial.