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. 2021 Mar 29;7(9):4136–4163. doi: 10.1021/acsbiomaterials.1c00030

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© 2021 The Authors. Published by American Chemical Society

Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).

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In vivo effect of a SAP biofunctionalized with the adhesive molecule IKVAV and the growth factor GDNF in a Parkinson’s disease murine model. (a, b) The effect of the functionalized hydrogel is more pronounced than the cell implanted alone, as shown by the GFP+ cell density 10 weeks post-transplantation. The transplant has different outcomes in vivo, where (c) the cell line alone showed a lower graft survival than (d) the cells with the SAP N-fluorenylmethyloxycarbonyl (Fmoc)-DIKVAV and (e) the SAP combined with the GDNF growth factor. Reproduced with permission from ref (282). Copyright 2017 John Wiley and Sons.