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. 2021 Sep 6;24(5):775. doi: 10.3892/mmr.2021.12415

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Copyright: © Lin et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — PHI treatment suppresses inflammation of LPS-induced BEAS-2B cells. pcDNA3.1-MMP8 was constructed and the expression levels of MMP8 were measured via (A) reverse transcription-quantitative PCR and (B) western blot analyses. ***P<0.001 vs. control and pcDNA3.1-NC. (C-E) Following transfection of pcDNA3.1-MMP8 into LPS-induced BEAS-2B cells pretreated with PHI, the expression levels of the inflammatory factors were measured via ELISA. ***P<0.001 vs. control; ^###P<0.001 vs. LPS group; ^∆∆∆P<0.001 vs. LPS + PHI group. (F) Following transfection of pcDNA3.1-MMP8 into LPS-induced BEAS-2B cells pretreated with PHI, the expression levels of the inflammation-associated factors were measured via western blotting. ***P<0.001 vs. control; ^###P<0.001 vs. LPS group; ^∆P<0.05, ^∆∆∆P<0.001 vs. LPS + PHI group. PHI, phillygenin; LPS, lipopolysaccharide; NC, negative control; cox-2, cyclooxygenase-2; iNOS, inducible nitric oxide synthase.