Table 4.

The standardized incidence ratio of TB in patients with cancer exposed to ICIs

	Standardized TB incidence rate*	95% CI	TB incidence rate in general population*	95% CI	Standardized incidence ratio	95% CI	P value
ICI exposure
Total	494.4	492.3 to 496.5	61.4	60.6 to 62.1	8.1	8.0 to 8.2	<0.001
Male	428.2	425.3 to 431.0	71.6	70.4 to 72.2	6.0	5.9 to 6.1	<0.001
Female	559.3	556.1 to 562.5	51.4	50.4 to 52.3	10.9	10.7 to 11.1	<0.001
ICI non-exposure
Total	502.6	500.5 to 504.8	61.4	60.6 to 62.1	8.2	8.1 to 8.3	<0.001
Male	600.0	596.7 to 603.4	71.6	70.4 to 72.2	8.4	8.2 to 8.5	<0.001
Female	407.1	404.4 to 409.9	51.4	50.4 to 52.3	7.9	7.8 to 8.1	<0.001

*Indicates incidence rate per 100,000 person-years.

ICI, immune checkpoint inhibitor; TB, tuberculosis.