Table 2.

All-cause mortality according to birth cohort and to age at diagnosis in patients with isolated PS and controls

	PS, total		Controls, total		Risk of mortality
	No of deaths among patients/total no of patients (%)		No of deaths among controls/total no of controls (%)		HR (95% CI)	P value
	Death events, n	Mortality rate per 100 000 person-years	Death events, n	Mortality rate per 100 000 person-years
All	88/3910 (2.3)		192/38 770 (0.5)		4.67 (3.61 to 5.99)	<0.0001
Birth period
1970–1979	15	149.2 (83.5–246.1)	39	37.3 (26.5–51.0)	4.02 (2.14 to 7.16)	<0.0001
1980–1989	23	171.0 (108.4–256.7)	48	34.5 (25.4–45.7)	4.98 (2.97 to 8.11)	<0.0001
1990–1993	24	137.2 (87.9–204.2)	46	25.8 (18.9–34.4)	5.35 (3.21 to 8.68)	<0.0001
2000–2009	14	84.9 (46.4–142.5)	33	20.1 (13.9–28.3)	4.25 (2.19 to 7.79)	<0.0001
2010–2016	12	246.9 (127.6–431.3)	26	54.0 (35.2–79.1)	4.61 (2.23 to 8.97)	<0.0001
Age at registration, years
0–1 year	71	8944.7 (6985.9–11 282.6)	64	813.4 (626.4–1038.7)	10.99 (7.84 to 15.45)	<0.0001
1–10 years	6	123.2 (45.2–268.1)	52	107.5 (80.3–140.9)	1.17 (0.45 to 2.53)	0.751
>10 years	11	79.2 (39.5–141.7)	76	54.7 (43.1–68.5)	1.47 (0.73 to 2.64)	0.249

PS, pulmonary stenosis.;