Table 3.

All-cause mortality in patients with isolated PS (with and without valve interventions) and controls, according to birth cohort, to age at diagnosis

	With valve intervention		No valve intervention
	No of deaths among patients with PS and valve interventions/total no of valve intervened patients with PS (%)	RR for mortality (95% CI, p value)	No of deaths among patients with PS and no intervention/total no of patients with no interventions PS (%)	RR for mortality (95% CI, p value)
	7/500 (1.4)	2.47 (0.99 to 5.36, 0.029)	81/3410 (2.4)	5.07 (3.87 to 6.60,<0.0001)
	No of death events/no total (%)	RR for mortality (95% CI)	No of death events/no total (%)	RR for mortality (95% CI)
Birth period
1970–1989	2/68 (2.9)	1.64 (0.24 to 6.02, 0.565)	36/611 (5.9)	5.07 (3.37 to 7.50,<0.0001)
1990–2016	5/432 (1.2)	3.22 (1.03 to 8.31, 0.018)	45/2799 (1.6)	5.10 (3.53 to 7.25,<0.0001)
Age at registration, years
0–10	7/452 (1.5)	3.00 (1.18 to 6.64, 0.008)	70/2702 (2.6)	7.85 (5.73 to 10.70,<0.0001)
>10	0/48 (0.0)	–	11/708 (1.6)	1.57 (0.78 to 2.84, 0.174)

PS, pulmonalis stenosis; RR, relative risk.;