Figure 5.

Transcriptomic analysis of therapeutic mechanisms associated with extracellular vesicles in Dsg2^mt/mt mice. (A) Heat map showing transcripts that are up- or down-regulated in Dsg2^mt/mt mouse hearts that were normalized partially or completely by extracellular vesicles (EV) treatment. (B) Selected genes involved in inflammation, fibrosis, or associated with heart failure that are rescued by extracellular vesicle treatment (abbreviations in Supplementary material online, Table S3). (C) Selected pathways up- or down-regulated in Dsg2^mt/mt mice compared with wild type and modified by extracellular vesicle therapy. Red bars indicate inflammatory associated pathways.