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. 2021 Sep 14;21:967. doi: 10.1186/s12913-021-06919-x

Table 2.

List of RSA drugs in South Korea

Brand name Active substance Type Start date (End date) Note
Activation ongoing
 Erbitux cetuximab refund 5-Mar-2014 re-evaluation for RSA (1-Jul-2018)
 Xtandi enzalutamide refund 1-Nov-2014 re-evaluation for RSA (13-Feb-2019)
 Soliris eculizumab refund 1-Oct-2015

refund pilot program (1-Oct-2012),

Essential drug

 Caprelsa vandetanib expenditure cap 1-Nov-2015 Under EEE
 Naglazyme galsulfase refund 1-Mar-2016

refund pilot program (1-Oct-2012),

Essential drug

 Stivarga regorafenib refund 1-Jun-2016
 Vimizim elosulfase alfa expenditure cap 1-Jun-2016 Under EEE
 Pomalyst pomalidomide refund 1-Jan-2017
 Defitelio defibrotide expenditure cap 1-Jun-2017 Under EEE
 Perjeta pertuzumab

time cap

per patient

1-Jun-2017
 Zelboraf vemurafenib expenditure cap 1-Jul-2017 Under EEE
 Kadcyla trastuzumab emtansine utilization cap 3-Aug-2017
 Opdivo nivolumab

refund +

expenditure cap

21-Aug-2017
 Keytruda pembrolizumab

refund +

expenditure cap

21-Aug-2017
 Rafinlar dabrafenib expenditure cap 1-Sep-2017 Under EEE
 Lynparza olaparib expenditure cap 1-Oct-2017 Under EEE
 Meqsel trametinib expenditure cap 1-Nov-2017 Under EEE
 Ibrance palbociclib refund 6-Nov-2017
 Tagrisso osimertinib

discounted

treatment initiation

5-Dec-2017
 Tecentriq atezolizumab expenditure cap 12-Jan-2018 Under EEE
 Sylvant siltuximab expenditure cap 1-Feb-2018 Under EEE
 Kyprolis carfilzomib refund 5-Feb-2018
 Iclusig ponatinib expenditure cap 1-Apr-2018 Under EEE
 Imbruvica ibrutinib expenditure cap 1-Apr-2018 Under EEE
 Cyramza ramucirumab refund 1-May-2018
 Blincyto blinatumomab expenditure cap 1-Jul-2018 Under EEE
 Vyndaqel tafamidis expenditure cap 1-Oct-2018 Under EEE
 Cabometyx cabozantinib

refund +

expenditure cap

1-Feb-2019
 Praxbind idarucizumab expenditure cap 1-Feb-2019 Under EEE
 Darzalex daratumumab

refund +

expenditure cap

8-Apr-2019
 Spinraza nusinersen

refund +

expenditure cap

8-Apr-2019
Limited activation
 Olita olmutinib expenditure cap 15-Nov-2017 Under EEE
 Lartruvo olaratumab expenditure cap 1-Dec-2018 Under EEE
Expired activation
 Evoltra clofarabine CED

11-Dec-2013

(1-Dec-2018)

the first RSA drug,

conventional reimbursement after re-evaluation

 Revlimid lenalidomide refund

5-Mar-2014

(1-Dec-2017)

conventional reimbursement due to generic
 Xalkori crizotinib refund

1-May-2015

(1-May-2019)

conventional reimbursement due to alternative drugs after re-evaluation
 Pirespa pirfenidone refund

3-Oct-2015

(1-Nov-2017)

conventional reimbursement due to generic
 Diterin sapropterin expenditure cap

1-Nov-2017

(8-May-2019)

Under EEE,

conventional reimbursement due to generic

 Alecensa

alectinib

hydrochloride

expenditure cap

1-Oct-2017

(1-Dec-2018)

Under EEE,

conventional reimbursement due to alternative drugs after expansion of the indication

RSA risk sharing arrangement, EEE exemption of economic evaluation, CED coverage with evidence development