Table.

SARS-CoV-2 VOC and VOI (September 2021)

WHO labels	Pango lineage∗	GISAID clade†	Nextstrain clade‡	Additional amino acid changes shown	Earliest documented samples	Date of designation
Currently designated VOC
Alpha	B.1.1.7	GRY	20I (V1)	+S:484K//+S:452R	United Kingdom, 09/2020	18/12/2020
Beta	B.1.351	GH/501Y.V2	20H (V2)	+S:L18F	South Africa, 05/2020	12/18/2020
Gamma	P.1	GR/501Y.V3	20J (V3)	+S:681H	Brazil, 11/2020	11/01/2021
Delta	B.1.617.2	G/478K.V1	21A	+S:417N	India, 10/2020	VOI: 04/04/2021 VOC: 11/05/2021
Currently designated VOI
Eta	B.1.525	G/484K.V3	21D	–	Multiple countries, 12/2020	3/17/2021
Iota	B.1.526	GH/253G.V1	21F	–	US, 11/2020	3/24/2021
Kappa	B.1.526	G/452R.V3	21B	–	India, 10/2020	4/4/2021
Lambda	B.1.526	GR/452Q.V1	21G	–	Peru, 12/2020	6/14/2021
Lambda	B.1.526	GH	21H	–	Colombia, 01/2021	8/30/2021

VOC, variants of concern; VOI, variants of interest; WHO, World Health Organization.

^∗Pango lineage: The Phylogenetic Assignment of Named Global Outbreak Lineages (PANGOLIN) is a software tool developed by members of the laboratory of Andrew Rambaut, with an associated web application developed by the Centre for Genomic Pathogen Surveillance in South.

^†GISAID clade: Global initiative on sharing avian influenza data (GISAID) (https://www.gisaid.org/about-us/mission/).

^‡Nextstrain clade: Nextstrain is an open-source project to harness the scientific and public health potential of pathogen genome data (https://nextstrain.org/).