Table 2.

Top fifteen predicted interactions between pairs of pVOGs with annotated functions

pVOG A	pVOG B	P (interaction)	Annotation A	Annotation B
VOG5511	VOG6633	0.996	Tail fiber protein	Putative tail protein
VOG1215	VOG4545	0.996	Minor tail protein	Tape measure protein
VOG0796	VOG5106	0.996	Terminase small subunit	Phage terminase large subunit
VOG0205	VOG4586	0.996	Putative head taill joining protein	Major tail protein
VOG4553	VOG4773	0.994	Major capsid protein	Capsid portal protein Q
VOG4604	VOG5027	0.994	Portal protein	Head morphogenesis protein
VOG4565	VOG9941	0.994	Lysozyme	putative dna maturase b
VOG4555	VOG5106	0.994	Scaffolding protein	Phage terminase large subunit
VOG1190	VOG2368	0.994	Portal protein	Ribonucleoside triphosphate reductase, alpha chain
VOG4545	VOG9209	0.994	Tape measure protein	Minor tail protein L
VOG4545	VOG4599	0.994	Tape measure protein	Minor structural protein
VOG0641	VOG4763	0.994	Holin	Peptidase_S74 protein
VOG0641	VOG4763	0.994	Holin	Minor structural protein
VOG0692	VOG0796	0.994	Minor capsid protein	Terminase small subunit
VOG4811	VOG6163	0.994	Tape measure	Putative tape measure protein

P (interaction) represents the mean predicted probability of a pVOG pair to interact from 500 individual classifiers (decision trees) in the Random Forest. The full list is provided in Additional file 6