Table 2.
Dysregulated circRNAs in cancer
| CircRNA | Cancer type | Mechanism | Biological function | Ref |
|---|---|---|---|---|
| CircMEMO1 | hepatocellular carcinoma(HCC) | As a sponge for miR-106b-5p | Inhibit cancer cell proliferation, migration and invasion and increase the sensitivity of HCC cells to sorafenib treatment. | [46] |
| CircMALAT1 | hepatocellular carcinoma | Acts as mRNA translation brake and miR-6887-3p sponge | Promote the self-renewal of hepatocellular carcinoma stem cells | [47] |
| CircIGHG | oral squamous cell carcinoma | Acts as miR-142-5p sponge | Promote cancer cell invasiveness | [48] |
| CircMRPS35 | gastric cancer | Acts as a modular scaffold to recruit histone acetyltransferase KAT7 | Inhibit the proliferation and invasion of cancer cells | [49] |
| CircACTN4 | breast cancer | Binding far upstream element binding protein 1 | Promotes cancer cell proliferation, invasion and migration | [50] |
| CircSKA3 | breast cancer | Binds integrin β1 to induce Invadopodium formation | Promote cancer cell migration and invasion | [51] |
| CircNTRK2 | Esophageal cancer | Acts as a sponge for miR-140-3p | Promotes cancer cell proliferation, invasion and migration | [52] |
| CircNDUFB2 | non-small cell lung cancer (NSCLC) | As a scaffold to enhance the interaction between TRIM25 and IGF2BPs | A suppressor in the progression of NSCLC | [53] |
| CircSDHC | renal cell carcinoma(RCC) | Serves as a sponge for miR-127-3p | promotes RCC proliferation and aggression | [54] |
| CircPTPRA | bladder cancer | Interacting with IGF2BP1 | A tumor suppresso | [55] |
| CircZFR | cervical cancer | Bounding with SSBP1 to promote the assembly of CDK2/cyclin E1 complexes | Promotes cancer cell proliferation, invasion and migration | [55] |
| Circ2082 | glioblastoma | Binds to RMB3 and is part of the nuclear DICER complex | Reduce the tumorigenicity of glioblastoma cells | [56] |
| CircECE1 | osteosarcoma | Interacts with c-Myc to prevent speckle-type POZ-mediated c-Myc ubiquitination and degradation | Inhibit cancer cell proliferation and metastasis | [57] |
| CircBFAR | Pancreatic cancer | Sponge miR-34b-5p up-regulates the expression of mesenchymal-epithelial transition factor | Promotes cancer cell proliferation, invasion and migration | [58] |
| CircSPARC | Colorectal cancer | Sponge miR-485-3p to upregulate JAK2 expression | Enhances tumour growth and metastasis | [59] |
| Circ_0020710 | melanoma | Sponge miR-370-3p to up-regulate the expression of CXCL12 | Promotes cancer cell proliferation, invasion and migration | [60] |
| CircCRIM1 | nasopharyngeal carcinoma | Sponge miR-422a to block the suppression effect of miR-422a on FOXQ1 | Promote cancer cell migration and invasion | [61] |
| CircTNPO3 | Ovarian Cancer | Sponge miR-1299 to up-regulate NEK2 expression | Enhance the resistance of ovarian cancer cells to PTX | [62] |
| Circ_0002577 | endometrial cancer | Acts as a miR-625-5p sponge, upregulating IGF1R and activating the PI3K/Akt pathway | Promotes cancer cell proliferation, invasion and migration | [63] |