Fig. 2.

Mechanism of action of Concizumab relating to the different domains of TFPI. A physiological inhibition of the TF-FVIIa complex and the FXa complex through the binding of the K1 and K2 domains of TFPI to the respective coagulation factors. B concizumab binding to the K2 domain of TFPI and preventing the binding and inhibition of the TF-FVIIa complex and FXa by TFPI domains. TFPI tissue factor pathway inhibitor; K1 Kunitz domain 1; K2 Kunitz domain 2; K3 Kunitz domain 3; FVIIa activated factor VII; FXa activated factor X; TF tissue factor