Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Sep 15;22:269. doi: 10.1186/s13059-021-02485-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 1 — Mapping the evolving landscape of SEs reveals three distinct temporal patterns. a An overview of the interrogated systems in this study. b K-means clustering of the SE signal vectors across the five differentiation stages. Each row represents the signals of a SE during differentiation. Each SE is represented by 4 representative elements (sub-columns) generated by a linear interpolation approach (see the “Methods” section for details). c Average dynamic profiles of the three types of SEs during differentiation. Each SE is normalized to its maximum H3K27ac intensity during differentiation and the average profile is shown. d Genome browser snapshots showing typical examples for Con, TH, and DN SEs. The tracks shown are H3K27ac ChIP-seq signals. e Expression profile of the genes shown in d