Table 1.
Distribution of genotypes, alleles and phenotypes (allele carriers, carriage) of investigated MUC5B and DSP variants in the group of IPF patients and healthy control participants.
| IPF | Healthy controls | p valuea | |
|---|---|---|---|
| n = 210 | n = 205 | ||
| Sex | |||
| Female | 71 (33.8%) | 80 (39.0%) | 0.333 |
| Male | 139 (66.2%) | 125 (61.0%) | |
| Age at diagnosis (years), median, minimum–maximum | 70 (52–82) | 70 (51–88) | 0.270 |
| MUC5B rs35705950 | |||
| Genotype TT | 10 (4.8%) | 5 (2.4%) | <0.001 |
| Genotype GT | 106 (50.4%) | 38 (18.5%) | |
| Genotype GG | 94 (44.8%) | 162 (79.0%) | |
| Risk Allele T | 126 (30.0%) | 48 (11.7%) | <0.001 |
| Allele G | 294 (70.0%) | 362 (88.3%) | <0.001 |
| Carriage T | 116 (55.0%) | 43 (20.9%) | <0.001 |
| Carriage G | 200 (95.2%) | 200 (97.6%) | 0.200 |
| DSP rs2076295 | |||
| Genotype GG | 82 (39.0%) | 38 (18.5%) | <0.001 |
| Genotype GT | 87 (41.4%) | 102 (49.8%) | |
| Genotype TT | 41 (19.5%) | 65 (31.7%) | |
| Risk Allele G | 251 (59.8%) | 178 (43.4%) | <0.001 |
| Allele T | 169 (40.2%) | 232 (56.6%) | <0.001 |
| Carriage G | 169 (80.5%) | 140 (68.3%) | <0.001 |
| Carriage T | 128 (61.0%) | 167 (81.5%) | <0.001 |
IPF, idiopathic pulmonary fibrosis.
The distribution of investigated genotypes complied with the Hardy–Weinberg equilibrium.
a
Statistical significance was tested by chi-square test for categorical variables and by Kruskal–Wallis test for continuous variables.
Statistically significant results (p < 0.050) are shown in bold.