Table 3.
Outcomes | Median (range)a | Estimate of median change (range) | Comparison of change between groups (p) | ||
---|---|---|---|---|---|
In-person | Virtual | In-person | Virtual | ||
Worst CIPN painb | |||||
Baseline | 5.3 (3.0–9.1) | 5.7 (3.6–8.1) | − 1.2 (− 4.3–0.6) | − 1.7 (− 7.1 to 0.4) | 0.61 |
Eight weeks | 3.9 (1.0–8.1) | 4.0 (0–5.6) | |||
CIPN sensoryb | |||||
Baseline | 62.7 (25.9–77.8) | 44.4 (14.8–81.5) | − 13.0 (− 29.6 to 3.7) | − 11.1 (− 40.7 to 11.1) | 0.72 |
Eight weeks | 37.0 (11.1–66.7) | 29.6 (7.4–88.9) | |||
CIPN motorb | |||||
Baseline | 31.3 (12.5–71.4) | 29.2 (0–70.8) | − 13.7 (− 33.3 to 33.3) | − 8.3 (− 39.9 to 8.3) | 0.69 |
Eight weeks | 22.9 (8.3–52.4) | 20.8 (0–58.3) | |||
Pain interferenceb | |||||
Baseline | 58.5 (49.6–63.8) | 61.2 (41.6–69.7) | − 5.8 (− 19.6 to 11.2) | − 4.6 (− 22.2 to 8.0) | 0.78 |
Eight weeks | 53.0 (41.6–69.7) | 53.9 (41.6–63.8) | |||
Physical functionc | |||||
Baseline | 39.9 (35.6–45.5) | 43.5 (33.2–57.0) | 4.3 (− 7.6 to 9.1) | 3.5 (− 4.3 to 19.1) | 0.66 |
Eight weeks | 43.0 (35.6–48.3) | 48.3 (31.9–57.0) | |||
Anxietyb | |||||
Baseline | 57.7 (51.2–63.4) | 57.7 (40.3–71.2) | − 2.0 (− 10.9 to 10.2) | − 6.5 (− 17.4 to 3.9) | 0.21 |
Eight weeks | 57.6 (40.3–63.4) | 40.3 (40.3–71.2) | |||
Depressionb | |||||
Baseline | 53.2 (41–63.9) | 53.9 (41–63.9) | 0 (− 8.3 to 4.9) | 0 (− 12.9 to 1.7) | 0.92 |
Eight weeks | 53.9 (41–57.3) | 49.0 (41.0–63.9) | |||
Sleep impairmentb | |||||
Baseline | 58.2 (38.7–62.3) | 58.2 (35.2–66.3) | − 5.7 (− 13.4 to 24.6) | − 2.2 (− 21.6 to 7.1) | 0.99 |
Eight weeks | 55.6 (43.6–63.3) | 50.3 (30.0–69.5) | |||
Fatigueb | |||||
Baseline | 56.1 (33.7–64.6) | 55.1 (43.1–75.8) | − 7.8 (− 13.6 to 21.4) | − 5.5 (− 14.9 to 6.0) | 0.45 |
Eight weeks | 49.8 (46–55.1) | 48.6 (33.7–66.7) |
Note:
aIncreasing scores for the specified variables indicate worse symptoms, except for physical function, where higher scores represent greater function
bFor the estimate of median change, negative estimates indicate improvements in symptom severity, whereas positive estimates indicate worsening of symptom severity over time
cFor the estimate of median change, negative estimates indicate that function worsened over time, whereas positive estimates indicate that function improved over time