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. 2021 Sep 14;12(1):335–345. doi: 10.1515/tnsci-2020-0177

Figure 3.

Figure 3

PACS1 is targeted by miR-485-5p in pericytes. (a) The expression levels of PACS1, MON2, TCTA, SOX10, and PPARGC1A in pericytes transfected with miR-485-5p mimics or NC mimics were detected using RT-qPCR analysis. (b) The binding site between PACS1 and miR-485-5p was presented. (c) The luciferase reporter assay was employed to verify the binding between PACS1 and miR-485-5p in pericytes. (d) The protein level of PACS1 in pericytes overexpressing miR-485-5p was assessed using western blot analysis. (e) PACS1 expression in the hippocampus of WT mice or APP/PS1 mice (n = 10/group) was assessed using RT-qPCR. (f) The correlation between PACS1 expression and miR-485-5p expression in the hippocampus of APP/PS1 mice was evaluated through Pearson correlation analysis. ** p < 0.01.