Fig. 1.

Full atomistic models of S trimer within the viral membrane and ACE2 complex within the host cellular membrane. (a) Asymmetric 6vyb S trimer. One subunit is in blue-to-red rainbow color, the other two subunits are in silver and grey. Glycans are CPK sphere representation. (b, c) Two orthogonal views of two symmetric 6vxx models with glycans omitted. Computationally modeled extension of about 90 Å is indicated. (d) Symmetric 6m17 dimer of heterodimeric ACE2/B(0)AT complex. (e, f) Two orthogonal views of three dimers of ACE2/B(0)AT complex with the ACE2 in a closed conformation. See Fig. 1 for comparison with the closed and open-1 structures and Video 1A, 1B, and 1C for motions between them. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)