Figure 1.

Cyclodextrins modulate fibril formation and alignment in vitrified collagen cornea substitutes via interactions with collagen. a) Schematic demonstrating cyclodextrin–collagen interaction, ultimately influencing collagen ultrastructural organization and spacing. b) Gross comparison of CD/ Col materials with CV of different thicknesses. c) Gross image of 500 μm thickness implants manufactured using βCD-Suc and collagen to demonstrate optical clarity. d) Evidence of macroscale lamellar structures in the implants as evidenced by careful peeling of individual layers. e) Suture pullout testing set-up to measure suture retention of biomaterials. f) Peak load measurements to monitor suture retention strength of vitrigels (n = 6). Data are means ± SD, unpaired Student’s t-test, ***P < 0.0001