Product scope with respect to different substituted phenyl-Tzs for the Cu-mediated 18F-fluorination from stannane precursors.
| ||||
|---|---|---|---|---|
| R | Compound | Position | ||
| (-p, -m, -o) | 4 (-p) | 5 (-m) | 6 (-o) | |
| –CH3 | [18F]14 | —a | 14 ± 3b | —c |
| –OCH3 | [18F]15 | 4 ± 1 | 17 ± 3b | —c |
| –NHCOCH3 | [18F]16 | —a | 31 ± 3b | —d |
| –CONH2 | [18F]17 | —a | 24 ± 2b | —d |
| –CONHCH3 | [18F]18 | —a | 20 ± 3b | —d |
Stannane precursor could not be synthesized.
RCCs were determined by radio-HPLC and radio-TLC (n = 3).
Decomposed during the Cu-mediated 18F-fluorination.
Iodo-Tz intermediate could not be synthesized.