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| Compound | CC50 (μM) | IC50 (μM) | Selectivity indexb |
|---|---|---|---|
| 2k | 29.3 | 0.20 | 148.5 |
| 2u | 33.2 | 0.24 | 138.3 |
| 2r | 28.2 | 1.24 | 22.7 |
CC50, 50% cytotoxic concentration measured by viability assay (without virus infection); IC50, the viral RNA copies were reduced by 50% compared with the control (without compound treatment) in the secreted virions.
A selectivity index (CC50/IC50) of >10 is considered to have good potential for drug development.
