Table 5.

Definitions of final outcome domains.

1. Pain interference with daily living—how much pain interferes with engagement in social, physical, and recreational activities.

2. Pain severity—perception of the severity of pain including how intense pain is and how frequently it occurs.

3. Overall well-being—perception of overall (global) well-being (eg, satisfaction with health and life)

4. Sleep—quantity and quality of sleep (eg, problems with falling sleep).

5. Physical functioning—ability to perform physical activities

6. Emotional functioning—psychological and emotional well-being (such as experiencing anxiety or depression).

7. Adverse events—an unwanted symptom or reaction from a treatment (eg, stomach upset, vomiting, fatigue, etc.).