Conceptual and empirical links between high expression of each personality trait, fatigability, and age-related health outcomes. Each pathway represents an association between a specific personality trait with age-related health outcomes (e.g., high on conscientiousness→low fatigability→protective against age-related disability). Separately, personality and fatigability are shown to be early indicators of age-related disabilities. Evidence suggests personality is relatively stable after age 30, thus finding links between fatigability and personality—assessment and monitoring of certain personality traits may help predict functional vulnerabilities earlier in the lifespan. The thickness of lines symbolizes the degree of association found in the literature.