Table 2.
Association of Chronic Comorbid Conditions and Obstetrical Complications With Human Immunodeficiency Virus in Pregnancy
| Unadjusted OR (95% CI) | AOR (95% CI)a | |
|---|---|---|
| Primary outcomes | ||
| ≥2 Chronic comorbid conditions | 3.48 (3.07, 3.95) | 2.96 (2.58, 3.41) |
| Obstetric complication | .95 (.86, 1.05) | .84 (.75, .94) |
| Secondary outcomes | ||
| By comorbid condition disease system | ||
| Psychiatric | 4.67 (4.21, 5.18) | 5.13 (4.53, 5.80) |
| Pulmonary | 1.69 (1.51, 1.89) | 1.66 (1.47, 1.87) |
| Cardiovascular | 1.98 (1.74, 2.26) | 1.27 (1.09, 1.47) |
| Endocrine | .79 (.65, .96) | 1.02 (.84, 1.25) |
| Hematologic | 41.24 (31.02, 54.83) | 36.87 (25.80, 52.67) |
| Neurological | 2.34 (1.74, 3.14) | 3.24 (2.40, 4.36) |
| Other diseaseb | .32 (.20, .51) | .26 (.16, .41) |
| By specific obstetric/infant complication | ||
| Pre-eclampsia | .93 (.79, 1.09) | .80 (.67, .95) |
| Gestational diabetes | 1.05 (.87, 1.26) | .70 (.57, .87) |
| Very preterm birth <34 weeks | .82 (.67, 1.00) | .76 (.62, .94) |
| Gestational hypertension | .80 (.63, 1.03) | .90 (.69, 1.17) |
| Fetal growth restriction | 1.05 (.76, 1.47) | 1.45 (1.04, 2.01) |
| Other complicationc | 1.59 (1.21, 2.10) | 1.22 (.91, 1.63) |
| Other secondary outcomes | ||
| Chronic comorbid condition (any) | 1.95 (1.80, 2.11) | 1.89 (1.73, 2.06) |
| Preterm birth <37 weeks | 1.45 (1.31, 1.60) | 1.31 (1.17, 1.47) |
Abbreviations: AOR, adjusted odds ratio; CI, confidence interval; CSL, Consortium on Safe Labor; HIV, human immunodeficiency virus; IMPAACT P1025, International Maternal Pediatric Adolescent AIDS Clinical Trials Protocol P1025; OR, odds ratio.
aAORs and 95% CIs are the odds of having the given outcome among women with HIV in IMPAACT P1025 compared with women without HIV in CSL (ie, reference group). Generalized logistic regression with within-participant random effect to account for women with multiple deliveries during the study time period was used. Models adjusted for the following covariates: maternal age at delivery (continuous), maternal race/ethnicity (Black, Hispanic, White), parity (0, ≥1), US region (Northeast, West, Midwest, and South including Puerto Rico), and delivery year (continuous). Obstetrical complication model additionally adjusted for multiple gestation (yes or no) and history of preterm birth (yes or no).
bOther disease includes renal disease and gastrointestinal disease.
cOther complication includes placenta previa and fetal demise.