Table 2.
Incidence of Herpes Zoster per 100 000 Person-Years by Baseline Characteristics and Recombinant Zoster Vaccination Status From 2018 to 2019
| Unvaccinated | Vaccinated | Rate Ratioa (95% CI) | |||||
|---|---|---|---|---|---|---|---|
| No. of Cases | No. of Person-Years | Incidence Rate (95% CI) | No. of Cases | No. of Person-Years | Incidence Rate (95% CI) | ||
| Overall | 64 169 | 7 184 911 | 893.1 (886.2, 900.0) | 298 | 115 125 | 258.8 (230.6, 289.4) | .29 (.26, .32) |
| Age group (years)b | |||||||
| 50–59 | 15 424 | 2 252 215 | 684.8 (674.1, 695.7) | <11 | 2019 | <544.8 (282.9, 933.0) | <.80 (.44, 1.44) |
| 60–69 | 17 326 | 2 040 881 | 848.9 (836.4, 861.7) | >34 | 22 934 | >148.3 (103.8, 203.8) | >.17 (.12, .24) |
| 70–79 | 19 920 | 1 926 358 | 1034.1 (1019.8, 1048.5) | 161 | 65 423 | 246.1 (210.0, 286.1) | .24 (.20, .28) |
| 80+ | 11 499 | 965 456 | 1191.0 (1169.4, 1212.9) | 92 | 24 750 | 371.7 (300.8, 452.9) | .31 (.25, .38) |
| Sex | |||||||
| Male | 24 142 | 3 422 927 | 705.3 (696.4, 714.2) | 92 | 48 288 | 190.5 (154.2, 232.1) | .27 (.22, .33) |
| Female | 39 977 | 3 757 202 | 1064.0 (1053.6, 1074.5) | 206 | 66 458 | 310.0 (269.5, 354.2) | .29 (.25, .33) |
| Unknown | 50 | 4782 | 1045.6 (781.9, 1362.8) | 0 | 379 | 0.0 | 0.0 |
| Race/ethnicity | |||||||
| Asian | 2018 | 226 738 | 890.0 (851.7, 929.4) | 19 | 3968 | 478.9 (294.5, 727.5) | .54 (.34, .85) |
| Black | 5873 | 801 219 | 733.0 (714.4, 751.9) | 22 | 8702 | 252.8 (161.2, 373.6) | .34 (.23, .52) |
| Hispanic | 6053 | 706 369 | 856.9 (835.5, 878.7) | 16 | 5432 | 294.6 (172.8, 463.3) | .34 (.21, .56) |
| White | 43 606 | 4 683 783 | 931.0 (922.3, 939.8) | 218 | 85 339 | 255.5 (223.0, 290.9) | .27 (.24, .31) |
| Unknownc | 6619 | 766 801 | 863.2 (842.6, 884.2) | 23 | 11 685 | 196.8 (127.0, 288.6) | .23 (.15, .34) |
| Insurance type | |||||||
| Commercial | 25 422 | 3 501 871 | 726.0 (717.1, 734.9) | 22 | 11 320 | 194.4 (124.0, 287.2) | .27 (.18, .41) |
| Medicare Advantage | 38 747 | 3 683 040 | 1052.0 (1041.6, 1062.5) | 276 | 103 805 | 265.9 (235.7, 298.5) | .25 (.22, .28) |
| Region | |||||||
| Midwest | 16 266 | 1 779 281 | 914.2 (900.2, 928.3) | 93 | 36 028 | 258.1 (209.2, 314.2) | .28 (.23, .35) |
| Northeast | 8704 | 959 821 | 906.8 (887.9, 926.0) | 30 | 12 647 | 237.2 (162.1, 332.5) | .26 (.18, .37) |
| South | 31 038 | 3 350 810 | 926.3 (916.0, 936.6) | 141 | 51 904 | 271.7 (229.2, 319.0) | .29 (.25, .35) |
| West | 8115 | 982 217 | 826.2 (808.3, 844.3) | 34 | 14 527 | 234.0 (163.9, 321,8) | .28 (.20, .40) |
| Unknownd | 46 | 112 782 | 40.8 (30.1, 53.7) | 0 | 19 | 0.0 | 0.0 |
Abbreviations: CI, confidence interval; OLDW, OptumLabs Data Warehouse.
aRate ratio was computed as incidence rate in vaccinated group/incidence rate in the unvaccinated group.
bFor cell counts <11, OptumLabs requires values to be reported as <11 rather than reporting actual values in order to protect patient privacy. In addition, in order to prevent back-calculation, the value in another cell in the same subgroup is lowered and reported with a greater than sign to keep the total case count the same. The incidence rate for vaccinated person-time for ages 50–59 is calculated for n = 11 to further prevent back-calculation and maintain individual privacy.
cThe unknown race/ethnicity category includes individuals with either unknown or missing race/ethnicity.
dThe unknown region category includes individuals in either unknown or other regions. In OLDW, the predefined region categories are Midwest, Northeast, South, West, Other, Unknown. The Other and Unknown categories were combined given the low prevalence of herpes zoster in each individual group.