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. 2021 Sep 3;7(36):eabe5671. doi: 10.1126/sciadv.abe5671

Fig. 10. Schematic abstract, NANOG expression ameliorates the hallmarks of cellular senescence.

Fig. 10.

Senescent cells expressing NANOG increased autophagy flux to remove dysfunctional mitochondria, reduce cellular size, and restore the ATP/protein content to the levels of their younger counterparts. NANOG also improved nuclear integrity, reduced the frequency of CCFs, and restored the heterochromatin marks H3K9me3 and H3K27me3. DDR was enhanced in NANOG expressing cells to repair DNA DSBs and allow reentry to the cell cycle. Notably, NANOG restored the pool of Pax7+ myogenic progenitors and induced eMyHC+ myofiber formation in a mouse model of premature aging.